What is CBD?
How Does it Work in the Body?
Where does CBD really come from?
- endocannabinoids - this is what your body makes on demand and consists primarily of 2-AG and AEA. There are others but these are the most known.
- Receptors - CB1 and CB2 receptors are on the surface of cells and are found all over the body in varying degree
- Enzymes - MAGL and FAAH are the primary enzymes whose role it is to break down cells and eliminate them
- diet poor in Omega 3 fatty acids and too high in Omega 6 fatty acids. Research is showing that obesity and overweight patients with diabetes could potentially decrease endocannabinoids resulting in deficiency.
- Lack of exercise can result in deficiency. Testing has shown increased levels of enzymes that help break down anandamide which helps maintain ECS balance. Exercise also boosts levels of CB1 receptors in the brain helping with spatial memory and pain perception.
- We all need Vitamin D and most Americans don’t have enough. You can get Vitamin D from the sun or UV light from tanning beds. The cells that contain the pigment that protects your skin from damage are called melanin. Endocannabinoids are prominent in melanin. So even though we have been told to avoid too much sun or tanning bed exposure, if we don’t get enough, we are actually at risk of developing skin cancer. You have to get your vitamin D checked by your provider and try to get it up to the higher end of normal.
- Sleep!!! It’s so important! If you have a chronic problem that interferes with sleep or maybe you just skimp on sleep your ECS will be affected. Poor sleep means increased levels of 2-AG and anandamide. Not enough sleep will increase hunger and weight gain.
- Circadian Rhythm - this is the natural rhythm that is your internal clock that helps regulate sleep/wake cycles. Research is ongoing to determine if the endocannabinoids regulate the clock or if the clock regulates the endocannabinoids.
- Nicotine- smoking results in inflammation in the brain, lungs and body. A deficiency of endocannabinoids combined with smoking, may trigger lung cancer.
- Alcohol - this can result in deficiency of endocannabinoids. When you drink the anandamide in the brain gets blocked and CB1 receptors are decreased in number.
- Stress- acute and chronic can wreak havoc on the ECS and is a topic for another day.
- Medications and chemotherapy can affect this system as well
1). Endocannabinoids (small molecules produced inside the body that activate cannabinoid receptors called anandamide and 2-AG)
2). Enzymes (FAAH & MAGL) that help break endocannabinoids down
3). Receptors (CB1 and CB2) that are found on the surface of cells in animals and humans. They manage memory, digestion, immune response, inflammation, appetite, pain, motor function, blood pressure, bone development and growth, neuroprotection and more in an effort to maintain homeostasis or balance.
CB1 receptors are abundant in the brain and central nervous system.
CB2 receptors are abundant everywhere else. They are just waiting for something to come along and unlock them and that would be CBD or THC.
Your endocannabinoid system is very different from mine. We make our own Endocannabinoid's and that is based on different factors like stress, health, emotions and more.
To give you a simple explanation, your endocannabinoid receptor is sitting there waiting for something to bind to it to unlock it so it can become activated. That something is CBD/THC which are called phytocannabinoids.
When you are faced with illness, or inflammation, chemical exposures like medications, or trauma your endocannabinoid system recognizes these issues and makes more anandamide and 2-AG (endocannabinoids) in an effort to maintain balance.
Using CBD with a small amount of THC will activate that system and help balance become a reality!!
Learning about this concept has been a fascinating experience for me especially coming from the 70’s where it was sex, drugs and rock and roll!!
This plant has changed and the stigma of the plant is changing! Let’s use it for what it was intended- as medicine to bring balance to our health!!
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Why is exercise so important?
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